Low-Affinity Major Histocompatibility Complex-Binding Peptides in Type 1 Diabetes
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Low-Affinity Major Histocompatibility Complex–Binding Peptides in Type 1 Diabetes
Type 1 diabetes is characterized by T-cell–mediated destruction of insulin-producing -cells. The strong association between autoimmune diabetes and certain susceptible major histocompatibility complex (MHC) class II alleles suggests that T-cell activation by self-peptides presented via these MHC class II alleles plays a critical role in the disorder’s pathogenesis. A diverse repertoire of T-cel...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2008
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db08-0530